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Consider alternant therapies that aren't moderate CYP3A inducers in the course of remedy with mitapivat. If struggling to avoid coadministration, keep an eye on Hb and titrate outside of 50 mg BID, if necessary, but tend not to exceed mitapivat dose of 100 mg BID. .pentobarbital will lower the level or impact of disopyramide by affecting hepatic/in